yilian
27-07-2008, 04:20 PM
Thymine is a pyrimidine derivative and one of the major component bases of nucleotides and nucleic acid DNA.
However, for thymine auxotrophic microorganisms undergo cell death in response to thymine starvation. Direct effects are breaking of single and double stranded DNA. Indirect effects are elimination of plasmids, loss of transforming ability, filamentation, charges in pool sizes of various nucleotides and nucleosides and in the excretion, and phage induction.
These are the information that I found from internet regarding Thymineless Death (TLD).
Did anyone know more information and perhaps could explain about this?
Since that most of the TLD cases occur in bacterias and other microorganisms, is it related to human as well?
Thank you.
Sincerely,
yilian.
However, for thymine auxotrophic microorganisms undergo cell death in response to thymine starvation. Direct effects are breaking of single and double stranded DNA. Indirect effects are elimination of plasmids, loss of transforming ability, filamentation, charges in pool sizes of various nucleotides and nucleosides and in the excretion, and phage induction.
These are the information that I found from internet regarding Thymineless Death (TLD).
Did anyone know more information and perhaps could explain about this?
Since that most of the TLD cases occur in bacterias and other microorganisms, is it related to human as well?
Thank you.
Sincerely,
yilian.